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What is Sildenafil?

Sildenafil is a prescription medication in the PDE5 inhibitor class. It helps men with erectile dysfunction achieve and maintain an erection when sexually aroused by increasing blood flow to the penis. In a separate formulation, sildenafil is also approved at higher doses for adults with pulmonary arterial hypertension (PAH). It is commonly available as tablets in strengths such as 25 mg, 50 mg and 100 mg.

In regular medical use, sildenafil does not cure erectile dysfunction or PAH. It improves the body's natural response to sexual stimulation. It should be used only by patients whose clinician has confirmed ED or PAH and who do not have contraindicating conditions. Because it affects blood flow, it requires careful medical supervision and consideration of other medications you may take.

What conditions does it treat?

The primary use of sildenafil is erectile dysfunction, the persistent difficulty in achieving or maintaining an erection sufficient for sexual activity. It can restore sexual function for many men who have not responded well to other treatments. The drug is also prescribed for PAH in adults at specialized doses to improve exercise capacity and symptoms when directed by a clinician. It is not intended for use in women or children.

A clinician will determine whether sildenafil is appropriate for you and will consider other heart, liver or kidney conditions that may affect safety. Do not take it if you have certain medical conditions or are taking nitrates. Adherence to the prescribed plan helps reduce risk and maximize the chance of an effective response.

How does it work?

Sildenafil belongs to PDE5 inhibitors. When a man is sexually aroused, the body releases nitric oxide in the penis, starting the production of cGMP. Sildenafil blocks the enzyme PDE5, slowing cGMP breakdown. The result is relaxed smooth muscle and increased blood flow to the penis, allowing an erection to occur with sexual stimulation. The effect depends on arousal and can vary from person to person. It does not force an erection; it enhances a normal physiological response.

Because it influences blood flow, sildenafil can interact with some medicines and health conditions. It is important to follow the prescription exactly and to discuss any changes in your health with your clinician before continuing use.

Safety and precautions

Do not take sildenafil with nitrates or certain heart medicines, because the combination can cause a dangerous drop in blood pressure. Tell your clinician about all medicines you take, including prescription drugs, over‑the‑counter medicines, vitamins and herbal supplements.

Common side effects include headache, facial flushing, indigestion, nasal congestion and dizziness. Some people notice changes in vision or hearing. If an erection lasts longer than four hours, seek urgent medical help (priapism). If you have chest pain, fainting, or severe dizziness, stop using sildenafil and contact a clinician immediately.

Sildenafil is not approved for use in children. People with severe liver or kidney disease, very low blood pressure, recent heart attack or stroke, or certain eye conditions should use the medication only under medical supervision and with careful monitoring. If you have a history of prolonged erections or these risks, a clinician may adjust your plan or suggest alternatives.

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